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Methodological approaches in application of synthetic lethality screening towards anticancer therapy
A promising direction in the development of selective less toxic cancer drugs is the usage of synthetic lethality concept. The availability of large-scale synthetic low-molecular-weight chemical libraries has allowed HTS for compounds synergistic lethal with defined human cancer aberrations in activ...
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| 主要作者: | |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676542/ https://ncbi.nlm.nih.gov/pubmed/19319136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605000 |
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