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Rethinking ALS: the FUS about TDP-43

Mutation in TDP-43, a DNA/RNA binding protein, causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Combination of its mislocalization in most incidences of sporadic ALS (as well as other neurodegenerative disorders) with discovery of ALS-causing mutations in FUS/TLS, another DNA/RNA bin...

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Autores principales: Lagier-Tourenne, Clotilde, Cleveland, Don W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110083/
https://ncbi.nlm.nih.gov/pubmed/19303844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.006
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