Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria

Mitoferrin1 is 1 of 2 homologous mitochondrial iron transporters and is required for mitochondrial iron delivery in developing erythroid cells. We show that total deletion of Mfrn1 in embryos leads to embryonic lethality. Selective deletion of Mfrn1 in adult hematopoietic tissues leads to severe ane...

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Autors principals: Troadec, Marie-Berengere, Warner, David, Wallace, Jared, Thomas, Kirk, Spangrude, Gerald J., Phillips, John, Khalimonchuk, Oleh, Paw, Barry H., Ward, Diane McVey, Kaplan, Jerry
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109720/
https://ncbi.nlm.nih.gov/pubmed/21310927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-319483
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