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Specific iron chelators determine the route of ferritin degradation

Deferoxamine (DFO) is a high-affinity Fe (III) chelator produced by Streptomyces pilosus. DFO is used clinically to remove iron from patients with iron overload disorders. Orally administered DFO cannot be absorbed, and therefore it must be injected. Here we show that DFO induces ferritin degradatio...

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Autors principals: De Domenico, Ivana, Ward, Diane McVey, Kaplan, Jerry
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777130/
https://ncbi.nlm.nih.gov/pubmed/19671920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-224188
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