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Specific iron chelators determine the route of ferritin degradation

Deferoxamine (DFO) is a high-affinity Fe (III) chelator produced by Streptomyces pilosus. DFO is used clinically to remove iron from patients with iron overload disorders. Orally administered DFO cannot be absorbed, and therefore it must be injected. Here we show that DFO induces ferritin degradatio...

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Bibliografiske detaljer
Main Authors: De Domenico, Ivana, Ward, Diane McVey, Kaplan, Jerry
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777130/
https://ncbi.nlm.nih.gov/pubmed/19671920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-224188
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