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Specific iron chelators determine the route of ferritin degradation

Deferoxamine (DFO) is a high-affinity Fe (III) chelator produced by Streptomyces pilosus. DFO is used clinically to remove iron from patients with iron overload disorders. Orally administered DFO cannot be absorbed, and therefore it must be injected. Here we show that DFO induces ferritin degradatio...

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Bibliografski detalji
Glavni autori: De Domenico, Ivana, Ward, Diane McVey, Kaplan, Jerry
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777130/
https://ncbi.nlm.nih.gov/pubmed/19671920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-224188
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