Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria

Mitoferrin1 is 1 of 2 homologous mitochondrial iron transporters and is required for mitochondrial iron delivery in developing erythroid cells. We show that total deletion of Mfrn1 in embryos leads to embryonic lethality. Selective deletion of Mfrn1 in adult hematopoietic tissues leads to severe ane...

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Detalhes bibliográficos
Main Authors: Troadec, Marie-Berengere, Warner, David, Wallace, Jared, Thomas, Kirk, Spangrude, Gerald J., Phillips, John, Khalimonchuk, Oleh, Paw, Barry H., Ward, Diane McVey, Kaplan, Jerry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109720/
https://ncbi.nlm.nih.gov/pubmed/21310927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-319483
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