Inhibition and Covalent Modification of Tyrosine Hydroxylase by 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite

Parkinson's disease (PD) is a neurodegenerative disorder marked by the selective loss of dopaminergic neurons, leading to a decrease of the neurotransmitter dopamine (DA). DA is metabolized by monoamine oxidase to 3,4-dihydroxyphenyacetaldehyde (DOPAL). While the mechanism of pathogenesis of PD...

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Bibliographic Details
Main Authors: Mexas, Lydia M., Florang, Virginia R., Doorn, Jonathan A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109233/
https://ncbi.nlm.nih.gov/pubmed/21514317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2011.03.013
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