Antioxidant-Mediated Modulation of Protein Reactivity for 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is an endogenously produced toxic aldehyde. It is a bifunctional electrophile implicated in the loss of dopaminergic cells concomitant with Parkinson’s disease and neurodegeneration. DOPAL is known to react with proteins and amino acids such as N-acetyl Lys; o...

Full description

Saved in:
Bibliographic Details
Published in:Chem Res Toxicol
Main Authors: Anderson, David G., Florang, Virginia R., Schamp, Josephine H., Buettner, Garry R., Doorn, Jonathan A.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248556/
https://ncbi.nlm.nih.gov/pubmed/27268734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00528
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items