Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase by the Dopamine Metabolite, 3,4-Dihydroxyphenylacetaldehyde

BACKGROUND: The aldehyde metabolite of dopamine, 3,4-dihydroxyphenylacetaldehyde (DOPAL) is an endogenous neurotoxin implicated in Parkinson’s Disease. Elucidating protein targets of DOPAL is essential in understanding it’s pathology. The enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a...

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Gepubliceerd in:Biochem Biophys Res Commun
Hoofdauteurs: Vanle, Brigitte C., Florang, Virginia R., Murry, Daryl J., Aguirre, Arturo L., Doorn, Jonathan A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746426/
https://ncbi.nlm.nih.gov/pubmed/28830811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.08.067
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