Expression and Iron-Dependent Regulation of Succinate Receptor GPR91 in Retinal Pigment Epithelium

PURPOSE. GPR91, a succinate receptor, is expressed in retinal ganglion cells and induces vascular endothelial growth factor (VEGF) expression. RPE also expresses VEGF, but whether this cell expresses GPR91 is not known. Excessive iron is also proangiogenic, and hemochromatosis is associated with iro...

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Hlavní autoři: Gnana-Prakasam, Jaya P., Ananth, Sudha, Prasad, Puttur D., Zhang, Ming, Atherton, Sally S., Martin, Pamela M., Smith, Sylvia B., Ganapathy, Vadivel
Médium: Artigo
Jazyk:Inglês
Vydáno: Association for Research in Vision and Ophthalmology, Inc. 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109050/
https://ncbi.nlm.nih.gov/pubmed/21357408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6722
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