Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis

PURPOSE: Matriptase-2 (also known as TMPRSS6) is a critical regulator of the iron-regulatory hormone hepcidin in the liver; matriptase-2 cleaves membrane-bound hemojuvelin and consequently alters bone morphogenetic protein (BMP) signaling. Hemojuvelin and hepcidin are expressed in the retina and pla...

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Asıl Yazarlar: Gnana-Prakasam, Jaya P., Baldowski, Renee B., Ananth, Sudha, Martin, Pamela M., Smith, Sylvia B., Ganapathy, Vadivel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Molecular Vision 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000719/
https://ncbi.nlm.nih.gov/pubmed/24791141
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