Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis

PURPOSE: Hemochromatosis, an iron-overload disease, occurs as adult and juvenile types. Mutations in hemojuvelin (HJV), an iron-regulatory protein and a bone morphogenetic protein (BMP) coreceptor, underlie most of the juvenile type. Hjv(−/−) mice accumulate excess iron in retina and exhibit aberran...

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izdano v:Invest Ophthalmol Vis Sci
Main Authors: Arjunan, Pachiappan, Gnanaprakasam, Jaya P., Ananth, Sudha, Romej, Michelle A., Rajalakshmi, Veeranan-Karmegam, Prasad, Puttur D., Martin, Pamela M., Gurusamy, Mariappan, Thangaraju, Muthusamy, Bhutia, Yangzom D., Ganapathy, Vadivel
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2016
Teme:
Retinal Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824383/
https://ncbi.nlm.nih.gov/pubmed/27046124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17437
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