GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy

PURPOSE: Retinal pigment epithelium (RPE) expresses GPR109A, a receptor for the vitamin niacin and the ketone body β-hydroxybutyrate (β-HB). Because diabetes results in elevated levels of β-HB, here we studied expression of the receptor in diabetic retina. We also investigated its functional relevan...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Gambhir, Deeksha, Ananth, Sudha, Veeranan-Karmegam, Rajalakshmi, Elangovan, Selvakumar, Hester, Shanterian, Jennings, Eric, Offermanns, Stefan, Nussbaum, Julian J., Smith, Sylvia B., Thangaraju, Muthusamy, Ganapathy, Vadivel, Martin, Pamela M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627510/
https://ncbi.nlm.nih.gov/pubmed/22427566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8447
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