Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

Hypercholesterolemia and polymorphisms in the cholesterol exporter ABCA1 are linked to age-related macular degeneration (AMD). Excessive iron in retina also has a link to AMD pathogenesis. Whether these findings mean a biological/molecular connection between iron and cholesterol is not known. Here w...

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Publicado no:Biochim Biophys Acta
Main Authors: Ananth, Sudha, Gnana-Prakasam, Jaya P., Bhutia, Yangzom D., Veeranan-Karmegam, Rajalakshmi, Martin, Pamela M., Smith, Sylvia B., Ganapathy, Vadivel
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289134/
https://ncbi.nlm.nih.gov/pubmed/24462739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.01.010
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