Loss of Hfe Leads to Progression of Tumor Phenotype in Primary Retinal Pigment Epithelial Cells

PURPOSE. Hemochromatosis is a disorder of iron overload arising mostly from mutations in HFE. HFE is expressed in retinal pigment epithelium (RPE), and Hfe(−/−) mice develop age-related iron accumulation and retinal degeneration associated with RPE hyperproliferation. Here, the mechanism underlying...

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Main Authors: Gnana-Prakasam, Jaya P., Veeranan-Karmegam, Rajalakshmi, Coothankandaswamy, Veena, Reddy, Sushma K., Martin, Pamela M., Thangaraju, Muthusamy, Smith, Sylvia B., Ganapathy, Vadivel
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544423/
https://ncbi.nlm.nih.gov/pubmed/23169885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10312
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