Absence of Iron-regulatory Protein Hfe results in Hyperproliferation of Retinal Pigment Epithelium: Role of Cystine/Glutamate Exchanger

Hemochromatosis is an iron overload disorder with age-dependent oxidative stress and dysfunction in a variety of tissues. Mutations in HFE are responsible for most cases with hemochromatosis. We recently demonstrated that Hfe is expressed exclusively in the basal membrane of retinal pigment epitheli...

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Autores principales: Gnana-Prakasam, Jaya P., Thangaraju, Muthusamy, Liu, Kebin, Ha, Yonju, Martin, Pamela M., Smith, Sylvia B., Ganapathy, Vadivel
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719389/
https://ncbi.nlm.nih.gov/pubmed/19715555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090424
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