Induction of Cystine-Glutamate Transporter x(c )(-) by Human Immunodeficiency Virus Type 1 Transactivator Protein Tat in Retinal Pigment Epithelium

PURPOSE: The transactivator protein Tat encoded by the human immunodeficiency virus-1 (HIV-1) genome reduces glutathione levels in mammalian cells. Because the retina contains large amounts of glutathione, a study was undertaken to determine the influence of Tat on glutathione levels, γ-glutamyl tra...

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Detalhes bibliográficos
Main Authors: Bridges, Christy C., Hu, Huankai, Miyauchi, Seiji, Siddaramappa, Umapathy N., Ganapathy, Malliga E., Ignatowicz, Leszek, Maddox, Dennis M., Smith, Sylvia B., Ganapathy, Vadivel
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735043/
https://ncbi.nlm.nih.gov/pubmed/15326101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.03-1355
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