Transport via SLC5A8 (SMCT1) Is Obligatory for 2-Oxothiazolidine-4-Carboxylate to Enhance Glutathione Production in Retinal Pigment Epithelial Cells

PURPOSE. To evaluate the role of SLC5A8 in the transport of 2-oxothiazolidine-4-carboxylate (OTC) and to determine whether OTC augments glutathione production in RPE cells, thereby providing protection against oxidative stress. METHODS. SLC5A8-mediated transport of OTC was monitored in Xenopus laevi...

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Hlavní autoři: Babu, Ellappan, Ananth, Sudha, Veeranan-Karmegam, Rajalakshmi, Coothankandaswamy, Veena, Smith, Sylvia B., Boettger, Thomas, Ganapathy, Vadivel, Martin, Pamela M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Association for Research in Vision and Ophthalmology, Inc. 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176078/
https://ncbi.nlm.nih.gov/pubmed/21508099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6825
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