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Mutational Analysis of the Preferential Binding of Human Topoisomerase I to Supercoiled DNA
Human topoisomerase I binds DNA in a topology-dependent fashion with a strong preference for supercoiled DNAs of either sign over relaxed circular DNA. One hypothesis to account for this preference is that a second DNA binding site exists on the enzyme which mediates an association with the nodes pr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107988/ https://ncbi.nlm.nih.gov/pubmed/19740104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07270.x |
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