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Mutational Analysis of the Preferential Binding of Human Topoisomerase I to Supercoiled DNA

Human topoisomerase I binds DNA in a topology-dependent fashion with a strong preference for supercoiled DNAs of either sign over relaxed circular DNA. One hypothesis to account for this preference is that a second DNA binding site exists on the enzyme which mediates an association with the nodes pr...

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Bibliografiske detaljer
Main Authors: Yang, Zheng, Carey, James F., Champoux, James J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107988/
https://ncbi.nlm.nih.gov/pubmed/19740104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07270.x
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