Preferential binding of human topoisomerase I to superhelical DNA.

Eukaryotic type I DNA topoisomerase provides swivels for removing torsional strain from the DNA helix during transcription and DNA replication. Previously it has been shown that the enzyme is associated with actively transcribed genes and replicating DNA. Using an inactive mutant form of the protein...

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Bibliographic Details
Main Authors: Madden, K R, Stewart, L, Champoux, J J
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC394649/
https://ncbi.nlm.nih.gov/pubmed/7489729
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