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DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein
In cocrystal structures of human topoisomerase I and DNA, the enzyme is tightly clamped around the DNA helix. After cleavage and covalent attachment of the enzyme to the 3′ end at the nick, DNA relaxation requires rotation of the DNA helix downstream of the cleavage site. Models based on the cocryst...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC156254/ https://ncbi.nlm.nih.gov/pubmed/12711735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1031537100 |
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