Wird geladen...
Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality
Eukaryotic DNA topoisomerase I (Top1) is a monomeric protein clamp that functions in DNA replication, transcription, and recombination. Opposable “lip” domains form a salt bridge to complete Top1 protein clamping of duplex DNA. Changes in DNA topology are catalyzed by the formation of a transient ph...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2003
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC283496/ https://ncbi.nlm.nih.gov/pubmed/14585933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235886100 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|