Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality

Eukaryotic DNA topoisomerase I (Top1) is a monomeric protein clamp that functions in DNA replication, transcription, and recombination. Opposable “lip” domains form a salt bridge to complete Top1 protein clamping of duplex DNA. Changes in DNA topology are catalyzed by the formation of a transient ph...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Woo, Michael H., Losasso, Carmen, Guo, Hong, Pattarello, Luca, Benedetti, Piero, Bjornsti, Mary-Ann
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2003
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2235886100
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