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Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality
Eukaryotic DNA topoisomerase I (Top1) is a monomeric protein clamp that functions in DNA replication, transcription, and recombination. Opposable “lip” domains form a salt bridge to complete Top1 protein clamping of duplex DNA. Changes in DNA topology are catalyzed by the formation of a transient ph...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC283496/ https://ncbi.nlm.nih.gov/pubmed/14585933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235886100 |
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