Mutations in GNA11 in Uveal Melanoma

BACKGROUND: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas. METHODS: We sequenced exon 5 of GNAQ and GNA11, a paralo...

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Bibliografiske detaljer
Main Authors: Van Raamsdonk, Catherine D., Griewank, Klaus G., Crosby, Michelle B., Garrido, Maria C., Vemula, Swapna, Wiesner, Thomas, Obenauf, Anna C., Wackernagel, Werner, Green, Gary, Bouvier, Nancy, Sozen, M. Mert, Baimukanova, Gail, Roy, Ritu, Heguy, Adriana, Dolgalev, Igor, Khanin, Raya, Busam, Klaus, Speicher, Michael R., O’Brien, Joan, Bastian, Boris C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107972/
https://ncbi.nlm.nih.gov/pubmed/21083380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1000584
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