Mutations in GNA11 in Uveal Melanoma

BACKGROUND: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas. METHODS: We sequenced exon 5 of GNAQ and GNA11, a paralo...

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主要な著者: Van Raamsdonk, Catherine D., Griewank, Klaus G., Crosby, Michelle B., Garrido, Maria C., Vemula, Swapna, Wiesner, Thomas, Obenauf, Anna C., Wackernagel, Werner, Green, Gary, Bouvier, Nancy, Sozen, M. Mert, Baimukanova, Gail, Roy, Ritu, Heguy, Adriana, Dolgalev, Igor, Khanin, Raya, Busam, Klaus, Speicher, Michael R., O’Brien, Joan, Bastian, Boris C.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107972/
https://ncbi.nlm.nih.gov/pubmed/21083380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1000584
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