Mutations in GNA11 in Uveal Melanoma

BACKGROUND: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas. METHODS: We sequenced exon 5 of GNAQ and GNA11, a paralo...

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Huvudupphovsmän: Van Raamsdonk, Catherine D., Griewank, Klaus G., Crosby, Michelle B., Garrido, Maria C., Vemula, Swapna, Wiesner, Thomas, Obenauf, Anna C., Wackernagel, Werner, Green, Gary, Bouvier, Nancy, Sozen, M. Mert, Baimukanova, Gail, Roy, Ritu, Heguy, Adriana, Dolgalev, Igor, Khanin, Raya, Busam, Klaus, Speicher, Michael R., O’Brien, Joan, Bastian, Boris C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107972/
https://ncbi.nlm.nih.gov/pubmed/21083380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1000584
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