Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy

BACKGROUND: Myostatin is a potent muscle growth inhibitor that belongs to the Transforming Growth Factor-β (TGF-β) family. Mutations leading to non functional myostatin have been associated with hypermuscularity in several organisms. By contrast, Duchenne muscular dystrophy (DMD) is characterized by...

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Main Authors: Kemaladewi, Dwi U, Hoogaars, Willem MH, van Heiningen, Sandra H, Terlouw, Samuel, de Gorter, David JJ, den Dunnen, Johan T, van Ommen, Gert Jan B, Aartsma-Rus, Annemieke, ten Dijke, Peter, 't Hoen, Peter AC
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107769/
https://ncbi.nlm.nih.gov/pubmed/21507246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-4-36
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