The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice

Vectors based on adeno-associated virus (AAV) serotype 9 are candidates for in vivo gene delivery to many organs, but the receptor(s) mediating these tropisms have yet to be defined. We evaluated AAV9 uptake by glycans with terminal sialic acids (SAs), a common mode of cellular entry for viruses. We...

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Detaylı Bibliyografya
Asıl Yazarlar: Bell, Christie L., Vandenberghe, Luk H., Bell, Peter, Limberis, Maria P., Gao, Guang-Ping, Van Vliet, Kim, Agbandje-McKenna, Mavis, Wilson, James M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104778/
https://ncbi.nlm.nih.gov/pubmed/21576824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57367
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