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The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
Vectors based on adeno-associated virus (AAV) serotype 9 are candidates for in vivo gene delivery to many organs, but the receptor(s) mediating these tropisms have yet to be defined. We evaluated AAV9 uptake by glycans with terminal sialic acids (SAs), a common mode of cellular entry for viruses. We...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104778/ https://ncbi.nlm.nih.gov/pubmed/21576824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57367 |
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