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Impairment of the PD-1 pathway increases atherosclerotic lesion development and inflammation

OBJECTIVE: Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. We studied the contribution of PD-1 pathway in regulating T cells that promote atherosclerotic lesion formation and inflammation. METHOD...

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Autors principals: Bu, De-xiu, Tarrio, Margarite, Maganto-Garcia, Elena, Stavrakis, George, Tajima, Goro, Lederer, James, Jarolim, Petr, Freeman, Gordon J, Sharpe, Arlene H, Lichtman, Andrew H
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104026/
https://ncbi.nlm.nih.gov/pubmed/21393583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.224709
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