Statin-induced Kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses

The transcription factor kruppel-like factor 2 (KLF2) is required for the quiescent and migratory properties of naive T cells. Statins, a class of HMG-CoA reductase inhibitors, display pleiotropic immunomodulatory effects that are independent of their lipid-lowering capacity and may be beneficial as...

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Detalhes bibliográficos
Main Authors: Bu, De-xiu, Tarrio, Margarite, Grabie, Nir, Zhang, Yuzhi, Yamazaki, Hiroyuki, Stavrakis, George, Maganto-Garcia, Elena, Pepper-Cunningham, Zachary, Jarolim, Petr, Aikawa, Masanori, García-Cardeña, Guillermo, Lichtman, Andrew H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877947/
https://ncbi.nlm.nih.gov/pubmed/20440076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41384
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