In vivo stability and kinetics of absorption and disposition of 3' phosphopropyl amine oligonucleotides.

Development of oligonucleotide derivatives as therapeutic agents requires an understanding of their pharmacokinetic behavior. The in vivo disposition and stability of a prototype of such compounds are reported here. The compound studied, a relatively G-rich 38 base 3' phosphopropyl amine oligon...

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Main Authors: Zendegui, J G, Vasquez, K M, Tinsley, J H, Kessler, D J, Hogan, M E
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC310371/
https://ncbi.nlm.nih.gov/pubmed/1741256
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