In vivo stability and kinetics of absorption and disposition of 3' phosphopropyl amine oligonucleotides.

Development of oligonucleotide derivatives as therapeutic agents requires an understanding of their pharmacokinetic behavior. The in vivo disposition and stability of a prototype of such compounds are reported here. The compound studied, a relatively G-rich 38 base 3' phosphopropyl amine oligonucleo...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Zendegui, J G, Vasquez, K M, Tinsley, J H, Kessler, D J, Hogan, M E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1992
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310371/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1741256/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.2.307
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