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In vivo stability and kinetics of absorption and disposition of 3' phosphopropyl amine oligonucleotides.

Development of oligonucleotide derivatives as therapeutic agents requires an understanding of their pharmacokinetic behavior. The in vivo disposition and stability of a prototype of such compounds are reported here. The compound studied, a relatively G-rich 38 base 3' phosphopropyl amine oligonucleo...

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Sonraí bibleagrafaíochta
Foilsithe in:Nucleic Acids Res
Príomhchruthaitheoirí: Zendegui, J G, Vasquez, K M, Tinsley, J H, Kessler, D J, Hogan, M E
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Oxford University Press 1992
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310371/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1741256/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.2.307
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