Queuosine Deficiency in Eukaryotes Compromises Tyrosine Production through Increased Tetrahydrobiopterin Oxidation

Queuosine is a modified pyrrolopyrimidine nucleoside found in the anticodon loop of transfer RNA acceptors for the amino acids tyrosine, asparagine, aspartic acid, and histidine. Because it is exclusively synthesized by bacteria, higher eukaryotes must salvage queuosine or its nucleobase queuine fro...

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Detalhes bibliográficos
Main Authors: Rakovich, Tatsiana, Boland, Coilin, Bernstein, Ilana, Chikwana, Vimbai M., Iwata-Reuyl, Dirk, Kelly, Vincent P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103313/
https://ncbi.nlm.nih.gov/pubmed/21487017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.219576
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