Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide

QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ(0)) to 7-aminomethyl-7-deazaguanine (preQ(1)) in the biosynthetic pathway to the tRNA modified nucleoside queuosine. The QueF-catalyzed reaction incl...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Mohammad, Adeba, Bon Ramos, Adriana, Lee, Bobby W. K., Cohen, Spencer W., Kiani, Maryam K., Iwata-Reuyl, Dirk, Stec, Boguslaw, Swairjo, Manal A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372742/
https://ncbi.nlm.nih.gov/pubmed/28300774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom7010030
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