Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

Activating K-RAS mutations are the most frequent oncogenic mutations in human cancer. Numerous downstream signaling pathways have been shown to be deregulated by oncogenic K-ras. However, to date there are still no effective targeted therapies for this genetically defined subset of patients. Here we...

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Autori principali: Shaw, Alice T., Winslow, Monte M., Magendantz, Margaret, Ouyang, Chensi, Dowdle, James, Subramanian, Aravind, Lewis, Timothy A., Maglathin, Rebecca L., Tolliday, Nicola, Jacks, Tyler
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102385/
https://ncbi.nlm.nih.gov/pubmed/21555567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105941108
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