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Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress
Activating K-RAS mutations are the most frequent oncogenic mutations in human cancer. Numerous downstream signaling pathways have been shown to be deregulated by oncogenic K-ras. However, to date there are still no effective targeted therapies for this genetically defined subset of patients. Here we...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102385/ https://ncbi.nlm.nih.gov/pubmed/21555567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105941108 |
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