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Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
The insulin-like growth factor-I receptor (IGF-IR) was first cloned in 1986. Since then, intense work has defined classic phosphorelays activated via the IGF-IR, which regulate cell proliferation, apoptosis, motility, and fate. The understanding of the roles of hormones in cancer and the growth horm...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
2008
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101870/ https://ncbi.nlm.nih.gov/pubmed/18790742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0265 |
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