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Combining Targeted Therapies: Practical Issues to Consider at the Bench and Bedside

Numerous practical issues must be considered when combining targeted therapies in early clinical drug development. These include tumor resistance mechanisms, the existence of multiple, redundant signaling pathways, and the failure of single-agent therapies to achieve cures. The strategies adopted to...

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Main Authors: Rodon, Jordi, Perez, Jose, Kurzrock, Razelle
Formato: Artigo
Idioma:Inglês
Publicado: AlphaMed Press 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227881/
https://ncbi.nlm.nih.gov/pubmed/20080862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2009-0117
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