R1507, an Anti-Insulin-Like Growth Factor-1 Receptor (IGF-1R) Antibody, and EWS/FLI-1 siRNA in Ewing's Sarcoma: Convergence at the IGF/IGFR/Akt Axis

A subset of patients with Ewing's sarcoma responds to anti-insulin-like growth factor-1 receptor (IGF-1R) antibodies. Mechanisms of sensitivity and resistance are unknown. We investigated whether an anti-IGF-1R antibody acts via a pathway that could also be suppressed by small interfering (si)...

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Hauptverfasser: Huang, Helen J., Angelo, Laura S., Rodon, Jordi, Sun, Michael, Kuenkele, Klaus-Peter, Parsons, Henrique A., Trent, Jonathan C., Kurzrock, Razelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191161/
https://ncbi.nlm.nih.gov/pubmed/22022506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026060
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