BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma

Ewing sarcoma is driven by characteristic chromosomal translocations between the EWSR1 gene with genes encoding ETS family transcription factors (EWS-ETS), most commonly FLI1. However, direct pharmacological inhibition of transcription factors like EWS-FLI1 remains largely unsuccessful. Active gene...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Loganathan, Sudan N., Tang, Nan, Fleming, Jonathan T., Ma, Yufang, Guo, Yan, Borinstein, Scott C., Chiang, Chin, Wang, Jialiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190040/
https://ncbi.nlm.nih.gov/pubmed/27259270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9762
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