BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma

Ewing sarcoma is driven by characteristic chromosomal translocations between the EWSR1 gene with genes encoding ETS family transcription factors (EWS-ETS), most commonly FLI1. However, direct pharmacological inhibition of transcription factors like EWS-FLI1 remains largely unsuccessful. Active gene...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Loganathan, Sudan N., Tang, Nan, Fleming, Jonathan T., Ma, Yufang, Guo, Yan, Borinstein, Scott C., Chiang, Chin, Wang, Jialiang
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190040/
https://ncbi.nlm.nih.gov/pubmed/27259270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9762
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