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Mycobacterium tuberculosis embB Codon 306 Mutations Confer Moderately Increased Resistance to Ethambutol In Vitro and In Vivo

Ethambutol (EMB) is a major component of the first-line therapy of tuberculosis. Mutations in codon 306 of embB (embB306) were suggested as a major resistance mechanism in clinical isolates. To directly analyze the impact of individual embB306 mutations on EMB resistance, we used allelic exchange ex...

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Main Authors: Plinke, Claudia, Walter, Kerstin, Aly, Sahar, Ehlers, Stefan, Niemann, Stefan
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2011
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101421/
https://ncbi.nlm.nih.gov/pubmed/21444710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00007-10
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