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Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog
The capsaicin receptor TRPV1 is the principal transduction channel for nociception. Excessive TRPV1 activation causes pathological pain. Ideal pain mangement requires selective inhibition of hyperactive pain-sensing neurons, but sparing normal nociception. We sought to determine whether it is possib...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100990/ https://ncbi.nlm.nih.gov/pubmed/21536874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018550108 |
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