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Unrepaired clustered DNA lesions induce chromosome breakage in human cells
Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that are not well understood. Here, we used an in situ method to directly monitor induction and repair of clustered DNA lesions in individual cells. We showed, consistent with b...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100920/ https://ncbi.nlm.nih.gov/pubmed/21527720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016045108 |
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