Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture

DNA damage and consequent mutations initiate the multistep carcinogenic process. Differentiated cells have a reduced capacity to repair DNA lesions, but the biological impact of unrepaired DNA lesions in differentiated lung epithelial cells is unclear. Here, we used a novel organotypic human lung th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Asaithamby, Aroumougame, Hu, Burong, Delgado, Oliver, Ding, Liang-Hao, Story, Michael D., Minna, John D., Shay, Jerry W., Chen, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141259/
https://ncbi.nlm.nih.gov/pubmed/21421565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr149
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