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Unrepaired clustered DNA lesions induce chromosome breakage in human cells

Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that are not well understood. Here, we used an in situ method to directly monitor induction and repair of clustered DNA lesions in individual cells. We showed, consistent with b...

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Bibliografiske detaljer
Main Authors: Asaithamby, Aroumougame, Hu, Burong, Chen, David J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100920/
https://ncbi.nlm.nih.gov/pubmed/21527720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016045108
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