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Unrepaired clustered DNA lesions induce chromosome breakage in human cells

Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that are not well understood. Here, we used an in situ method to directly monitor induction and repair of clustered DNA lesions in individual cells. We showed, consistent with b...

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Hlavní autoři: Asaithamby, Aroumougame, Hu, Burong, Chen, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100920/
https://ncbi.nlm.nih.gov/pubmed/21527720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016045108
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