Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8(+) T-cell exhaustion in HIV infection

A highly complex network of coinhibitory and costimulatory receptors regulates the outcome of virus-specific CD8(+) T-cell responses. Here, we report on the expression patterns of multiple inhibitory receptors on HIV-specific, cytomegalovirus-specific, and bulk CD8(+) T-cell memory populations. In c...

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Détails bibliographiques
Auteurs principaux: Yamamoto, Takuya, Price, David A., Casazza, Joseph P., Ferrari, Guido, Nason, Martha, Chattopadhyay, Pratip K., Roederer, Mario, Gostick, Emma, Katsikis, Peter D., Douek, Daniel C., Haubrich, Richard, Petrovas, Constantinos, Koup, Richard A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100691/
https://ncbi.nlm.nih.gov/pubmed/21398582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-317297
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