High Production Rates Sustain In Vivo Levels of PD-1(high) Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance

Programmed Death 1 (PD-1) expression by human/simian immunodeficiency virus (HIV/SIV)-specific CD8 T cells has been associated with defective cytokine production and reduced in vitro proliferation capacity. However, the cellular mechanisms that sustain PD-1(high) virus-specific CD8 T cell responses...

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Bibliographische Detailangaben
Hauptverfasser: Petrovas, Constantinos, Yamamoto, Takuya, Price, David A., Rao, Srinivas S., Klatt, Nichole R., Brenchley, Jason M., Douek, Daniel C., Gostick, Emma, Angermann, Bastian R., Grossman, Zvi, Macallan, Derek C., Meier-Schellersheim, Martin, Koup, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754085/
https://ncbi.nlm.nih.gov/pubmed/23824823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01001-13
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